The Virotech Yersinia enterocolitica ELISA is intended for the qualitative and semiquantitative detection of specific IgG/IgA antibodies which are directed against antigens of the 70 Kb virulence plasmid of pathogenic Yersinia in human serum. The antigen used is a mixture of purified native Yops (Yersinia outer membrane proteins) and recombinant YopB, YopD and YopE. Antigens YopD and YopE have been found to be the immunodominant antigens in infections in IgG, IgM and IgA; in reactive arthritis, they are the dominant antigens in IgA. As a consequence, they allow reliable diagnosis. The determination of increased antibody levels makes a contribution to diagnosis of Yersinia induced arthritis. The test is not intended for diagnosing acute enteric diseases.
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